| 1 | Jasprit Bumrah vs Royal Challengers Bangalore Mumbai Indians | 29 Wickets vs RCB Bumrah has taken 29 wickets against RCB in his IPL career — the most by any bowler against a single opponent. His best figures of 5/10 against RCB in 2022 represent the most destructive single-match performance in this rivalry. Bumrah's pinpoint yorkers and ability to take wickets at any stage of the innings have made him RCB's most difficult opponent. | 29 | Royal Challengers Bangalore | Mumbai Indians | 5/10 |
| 2 | Yuzvendra Chahal vs Mumbai Indians RCB / RR | 22 Wickets vs MI The IPL's all-time wicket leader has taken 22 wickets against Mumbai Indians — the most against any single team by a spinner. Chahal's sharp leg-break and googly have been particularly effective against MI's right-hand dominated batting lineup, with memorable wickets of Rohit Sharma, Hardik Pandya and Suryakumar Yadav among his tallies. | 22 | Mumbai Indians | RCB, RR | 4/30 |
| 3 | Lasith Malinga vs Chennai Super Kings Mumbai Indians | 22 Wickets vs CSK Malinga's 22 wickets against CSK reflect the intensity of the IPL's greatest rivalry — MI vs CSK. His yorkers and slower balls were particularly effective against CSK's middle-order, and many of his most memorable IPL deliveries came in crucial matches and finals against the Men in Yellow. | 22 | Chennai Super Kings | Mumbai Indians | 4/28 |
| 4 | Sunil Narine vs Mumbai Indians Kolkata Knight Riders | 21 Wickets vs MI KKR's mystery spinner has taken 21 wickets against Mumbai Indians — his highest tally against any single team. Narine's variations were particularly difficult for MI's lineup, and his performances against MI during KKR's 2012 and 2014 title campaigns were consistently match-winning. | 21 | Mumbai Indians | KKR | 4/11 |
| 5 | Bhuvneshwar Kumar vs Royal Challengers Bangalore SRH | 21 Wickets vs RCB India's swing king has taken 21 wickets against RCB, with his powerplay swing bowling proving particularly effective against Virat Kohli and RCB's aggressive opening combinations. The SRH vs RCB rivalry produced several of Bhuvi's finest IPL performances. | 21 | Royal Challengers Bangalore | SRH | 4/15 |
| 6 | Dwayne Bravo vs Mumbai Indians Chennai Super Kings | 20 Wickets vs MI Bravo's 20 wickets against MI are a measure of his impact in the IPL's defining rivalry. As the death-over specialist for CSK, Bravo regularly produced match-winning spells against MI in finals and crucial matches, including famous performances in the 2010 and 2011 DLF Cup clashes. | 20 | Mumbai Indians | CSK | 4/42 |
| 7 | Amit Mishra vs Mumbai Indians Delhi Capitals | 19 Wickets vs MI India's veteran leg-spinner has taken 19 wickets against MI across multiple seasons — a reflection of how consistently Mishra could exploit the Feroz Shah Kotla and other Delhi conditions against MI's batting lineup. His three hat-tricks came across different opponents, but his 19 wickets against MI remain his best against any single side. | 19 | Mumbai Indians | Delhi Capitals | 4/18 |
| 8 | Harbhajan Singh vs Royal Challengers Bangalore Mumbai Indians | 18 Wickets vs RCB India's veteran off-spinner took 18 wickets against RCB across his Mumbai Indians career, with the Wankhede's natural spin assistance helping Harbhajan's sharply-turning deliveries find the edges and pads of RCB's batsmen. He is particularly remembered for his performances against Virat Kohli in the Wankhede rivalry. | 18 | Royal Challengers Bangalore | MI | 4/12 |
| 9 | Ravichandran Ashwin vs Rajasthan Royals CSK / KXIP / DC | 18 Wickets vs RR India's off-spin legend accumulated 18 wickets against Rajasthan Royals across his career for multiple franchises. Ashwin's carrom ball and varied deliveries have proved consistently effective against RR's batting lineup, including memorable performances at home grounds in Chennai, Pune and Delhi. | 18 | Rajasthan Royals | CSK, KXIP, DC | 4/21 |
| 10 | Rashid Khan vs Mumbai Indians SRH / GT | 17 Wickets vs MI Afghanistan's leg-spin genius has taken 17 wickets against MI — his highest tally against any single team. Rashid's unreadable variations have troubled MI's batsmen consistently, with his googly proving especially effective against right-handers who struggle to pick his variations out of the hand. | 17 | Mumbai Indians | SRH, GT | 4/24 |
| 11 | Yuzvendra Chahal vs Chennai Super Kings RCB / RR | 17 Wickets vs CSK Chahal's second-highest tally against a single team is 17 wickets against CSK, where his wrist-spin variations have repeatedly troubled MS Dhoni's middle order. His performances against CSK's rotating middle-order lineup — featuring Raina, Dhoni and Jadeja — have produced some of his most memorable wickets. | 17 | Chennai Super Kings | RCB, RR | 4/26 |
| 12 | Piyush Chawla vs Royal Challengers Bangalore KXIP / KKR / CSK / MI | 17 Wickets vs RCB The veteran leg-spinner accumulated 17 wickets against RCB across multiple franchises — his consistency against the Bangalore lineup reflecting the effectiveness of his well-flighted leg-spin in conditions that suit wrist-spin. | 17 | Royal Challengers Bangalore | KXIP, KKR, CSK, MI | 4/17 |
| 13 | Trent Boult vs Royal Challengers Bangalore MI / RR / DC | 16 Wickets vs RCB New Zealand's left-arm swing specialist has taken 16 wickets against RCB across multiple franchises, with his left-arm angle into right-handers and ability to generate edges off Virat Kohli and RCB's top order producing consistently memorable dismissals. | 16 | Royal Challengers Bangalore | MI, RR, DC | 4/18 |
| 14 | Mohammed Shami vs Kolkata Knight Riders DD / PBKS / GT | 15 Wickets vs KKR India's swing spearhead has taken 15 wickets against KKR across multiple franchises — his most productive rivalry. Shami's ability to find late swing and seam at Eden Gardens, one of the most swing-friendly IPL venues, has made KKR a particularly productive opponent for him. | 15 | Kolkata Knight Riders | DD, PBKS, GT | 4/11 |
| 15 | Kagiso Rabada vs Royal Challengers Bangalore DC / PBKS / KKR | 15 Wickets vs RCB South Africa's pace spearhead has taken 15 wickets against RCB, with his pace, bounce and sharp yorker proving particularly effective against the Bangalore lineup. His best performance against them — in the 2020 season when his Delhi Capitals knocked RCB out — featured three wickets in a single over. | 15 | Royal Challengers Bangalore | DC, PBKS, KKR | 4/21 |
| 16 | Harshal Patel vs Chennai Super Kings RCB / PBKS | 15 Wickets vs CSK The death-over specialist took 15 wickets against CSK across his stints at RCB and PBKS. Harshal's slower balls, wide yorkers and leg-cutters were particularly effective against CSK's experienced middle-order, who found his variations difficult to read and time in the death overs. | 15 | Chennai Super Kings | RCB, PBKS | 4/29 |
| 17 | Praveen Kumar vs Kolkata Knight Riders RCB / KXIP / SRH | 14 Wickets vs KKR India's swing specialist took 14 wickets against KKR across multiple franchises, with the Eden Gardens' traditionally swing-friendly conditions suiting Praveen's style. His ability to extract movement even in conditions that usually don't favour swing made him particularly effective at this ground. | 14 | Kolkata Knight Riders | RCB, KXIP, SRH | 3/14 |
| 18 | Umesh Yadav vs Royal Challengers Bangalore DD / KKR / GT | 14 Wickets vs RCB The Chhattisgarh express took 14 wickets against his former team RCB after departing the franchise, with his express pace and back-of-a-length bowling proving effective at M. Chinnaswamy Stadium, where the bounce assists pacers who target the pitch hard. | 14 | Royal Challengers Bangalore | DD, KKR, GT | 4/23 |
| 19 | Sandeep Sharma vs Royal Challengers Bangalore KXIP / SRH / RR / MI | 14 Wickets vs RCB The swing bowling specialist accumulated 14 wickets against RCB across multiple franchises, with his ability to swing the ball in the powerplay producing consistent early dismissals against the Bangalore top order at Chinnaswamy and on neutral grounds. | 14 | Royal Challengers Bangalore | KXIP, SRH, RR, MI | 3/15 |
| 20 | Ravindra Jadeja vs Mumbai Indians CSK / RR | 13 Wickets vs MI India's finest all-rounder took 13 wickets against his most frequent rival — Mumbai Indians. Jadeja's quick-arm left-arm spin, sharp accuracy and natural ability to beat the bat in the middle overs made him effective against MI's powerful batting lineup in the IPL's defining franchise rivalry. | 13 | Mumbai Indians | CSK, RR | 4/10 |